XIAFLEX is the only nonsurgical treatment option for appropriate adult men with Peyronie's disease (PD) approved by the Food and Drug Administration (FDA).
Treatment with XIAFLEX involves a series of injections (1 to 4 treatment cycles about 6 weeks apart), given in office by a urologist who’s trained and experienced in treating adult men with PD. When paired with daily gentle stretching and straightening of the penis, XIAFLEX is proven to help gradually reduce erectile curvature. Individual results will vary.
You need to have the following 2 symptoms to start treatment with XIAFLEX:
A bump of scar tissue under the skin of the penis that can be felt.
Bent at least 30 degrees at the start of treatment.
Don't worry about figuring these things out for yourself.
A urologist can check for a Peyronie’s plaque and discuss all of your treatment options.
Find a urologist near you who can diagnose and treat PD.
Watch what other men and their partners have to say about treatment with XIAFLEX.
I wanted a doctor that has treated Peyronie’s disease... and I found one.
Here’s how XIAFLEX is thought to break down a Peyronie’s plaque.
There are enzymes in XIAFLEX that work together to gradually weaken and may break down the plaque that's causing your erection to curve. The exact way XIAFLEX works is unknown.
XIAFLEX is designed to target the complex fibers within the Peyronie's plaque that makes your penis bend when it is erect. Injecting XIAFLEX into other tissues of the penis that are made up of similar material may result in damage to those tissues and injury to the penis.
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FREQUENTLY ASKED QUESTIONS ABOUT PEYRONIE'S DISEASE (PD)
Q:
How is XIAFLEX different from other options?
A:
XIAFLEX is an FDA-approved injectable treatment for appropriate men with Peyronie's disease.
Where To Next?
Paying for Xiaflex
Eligible patients may qualify for copay assistance*
Learn More*Terms and conditions apply.
What is XIAFLEX®?
XIAFLEX is a prescription medicine used to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started.
It is not known if XIAFLEX is safe and effective in children under the age of 18.
Important Safety Information
Do not receive XIAFLEX if:
XIAFLEX can cause serious side effects, including:
Penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to fix the damaged area. Damage to your penis might not get better after a corporal rupture.
Symptoms of corporal rupture or other serious injury to your penis may include:
Call your healthcare provider right away if you have any of the symptoms of corporal rupture or serious injury to the penis listed above.
Do not have sex or any other sexual activity between the first and second injections of a treatment cycle.
Do not have sex or have any other sexual activity for at least 4 weeks after the second injection of a treatment cycle with XIAFLEX and after any pain and swelling has gone away.
XIAFLEX for the treatment of Peyronie's disease is only available through a restricted program called the XIAFLEX Risk Evaluation and Mitigation Strategy (REMS) Program.
Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX, because it contains foreign proteins.
Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX:
Back pain reactions. After receiving an injection of XIAFLEX for Peyronie’s disease, you may suddenly feel back pain, including severe lower back pain moving to your legs, feet, chest and arms. The back pain may also include spasms and make it hard to walk. These symptoms usually go away in 15 minutes or less, but may last longer.
Tell your healthcare provider right away if you have sudden back pain, chest pain, or hard time walking after an injection.
Fainting. Fainting (passing out) or near fainting can happen in men who receive XIAFLEX, especially if they have severe penile pain.
If you have dizziness or feel faint after receiving XIAFLEX, lie down until the symptoms go away.
Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, have a bleeding problem, received XIAFLEX for another condition, or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure.
What should I avoid while receiving XIAFLEX?
Avoid situations that may cause you to strain your stomach (abdominal) muscles, such as straining during bowel movements.
Do not use a vacuum erection device during your treatment with XIAFLEX.
XIAFLEX can cause serious side effects, including increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX may not be right for you.
The most common side effects with XIAFLEX for the treatment of Peyronie's disease include:
Tell your healthcare provider if you have any side effect that bothers you or does not go away.
These are not all of the possible side effects with XIAFLEX. For more information, ask your healthcare provider or pharmacist. You may report side effects to FDA at 1-800-FDA-1088.
Click for full Prescribing Information, including BOXED WARNING and Medication Guide.
Please see full Prescribing Information, including BOXED WARNING and Medication Guide.
What is XIAFLEX®?
XIAFLEX is a prescription medicine used to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started. It is not known if XIAFLEX is safe and effective in children under the age of 18.
IMPORTANT SAFETY INFORMATION
Do not receive XIAFLEX if the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra). You are allergic to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX.
